Prisma Health Vaccination Site In Greenville

Prisma Health’s vaccination site in Greenville opened on Monday, January 18 at 7 a.m. 

The vaccination site is located at 1 Kmart Plaza, Greenville, SC 29605.  Doors open from Monday-Friday, 7 a.m.-7 p.m.

The Greenville site is one of two Prisma mass vaccination sites opening in South Carolina today. The other site is in Columbia. Prisma Health plans to have 10,000 coronavirus vaccines each day at these locations.

Both sites are available only by appointment through the Center for Disease Control and Prevention’s Vaccine Administration Management System (VAMS). 

To make an appointment through the CDC’s Vaccine Administration Management System (VAMS), you can visit

A helpline is also available for those who do not have access to a computer, dial (833-277-4762) for assistance.

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